Kisiizi Waterfalls lie on Kyabamba River a few meters from Kisiizi Hospital in Rukungiri district which borders with Kabale in Western Uganda. The waterfalls are approximately 30 meters high on the Rushoma River that pours its water into Lake Edward.

Historically Kisiizi falls was a tragic place where unmarried pregnant Bakiga girls were punished to death. This practice was discontinued and what had been a place of despair became a place of hope and healing as the Church of Uganda established Kisiizi Hospital in 1958.

Kisiizi valley was also used by the British as a site for a flax processing factory in 1944, built to produce linen cords for parachutes used in the Second World War. Italian prisoners of war that had been captured in Abyssinia were brought to Kisiizi to provide labour.

Geographically, the falls are located in a forested area and gorge famous for bird life including endemic species like the Ross Turaco, Double Toothed barbet and the cinnamon Bee eater. As a tourist area, it is famed for the scenic environment and trekking activities. This area is also active from a social development perspective. The church of Uganda established a hospital, schools and a nursing institution to provide health care and educational opportunities to the surrounding community. The hospital management established a mini hydro power plant and water facility that serves the community of Kisiizi.